Creb Binding Protein

Also referred to as CREBB or CBP, Creb binding protein is a type of protein that is encoded by the CREBBP gene in humans. The Creb protein works through the activation of transcription. In this process, the interaction with transcription aspects is regulated by either one or more CREB domains. These domains include the nuclear receptor interaction domain, the CREB and MYB among others. Each of these domains is tightly bound to a sequence.

For the CREB binding protein to be made, there has to be instructions from the CREBBP gene. The protein plays a critical role in controlling the growth of cells and their division. Thus, it prompts the cells to mature so as to begin undertaking their specialized functions. According to some studies, this protein can also play a role in the formation of long term memories in animals. CREB binding protein is ideal for normal development before and after a sibling is born.

The main role of CREB binding protein is to activate transcription. This process is important because it aids that formation of a blue print of a gene so that proteins can be produced. In carrying out this function, CREB binding protein aids the connection of the factors of transcription. These factors are basically the proteins that trigger the process of transcription. They work in conjunction with other complex proteins to ensure that transcription occurs effectively. It is for this reason that some people refer to the CREB binding protein as a transcriptional co-activator.

Together with its homologue p300, CREB binding protein play crucial roles in a variety of cellular activities like repair of DNA, growth of cells, apoptosis and differentiation. Most studies have pointed out that the two can at times also act as tumor suppressors. In such an instance, their role is to cross-couple distinct patterns of gene expression in response to several stimuli. Their actions are mainly exerted through acetylation of histones among other regulatory proteins like p53.

Just like it is with p300, Creb binding protein has specific areas where it interacts with various transcription factors and co-factors. Most of the protein interactions with CREB binding protein are controlled through upstream signals. In certain scenarios, CREB binding protein is able to stimulate diverse functions of some transcriptional regulatory proteins. However, the most outstanding feature of CREB binding protein is its enzymatic activities.

Even though CREB binding procedure is important, this merit has been significantly underscored by the idea that genetic alterations are always linked to diseases in humans. There is proper documentation of CBP’s involvement in chromosomal translocations that are tied to hematologic malignancies.

Creb binding protein controls transcription through a variety of avenues. One of them is that it bridges gene-specific transcription factors with the basal transcriptional machinery. It also contributes to the formation of complex proteins. The other mechanism through which CREB binding protein controls transcription is through exhibition of acetyl-transferase activity.

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Reference:

http://ghr.nlm.nih.gov/gene/CREBBP

http://www.nature.com/cr/journal/v17/n4/full/cr200710a.html