Inherited deficiencies are not common but if they occur they have consequences. For example, according to Lipe & Ornestein (2011), people with protein S, proteins C, and antithrombin deficiency are more prone to develop deep vein thrombosis (DVT) as well as pulmonary embolism (PE) unlike those with no deficiency. Consequently, the use of contraceptive pill by the patient may have worsened the situation because of the estrogen component which is available in the oral contraceptive pills. Orrange (2019) urges that estrogen can trigger blood clot and this may cause one-sided leg swelling as well as on both legs.
The hypercoagulable state is usually is inherited or an acquired condition. Surgery, trauma, medical condition or medications are some of the acquired factors that increase the risk of hypercoagulable. Hypercoagulable conditions include cancer, obesity, pregnancy, oral contraceptive pills, heart attack, HIV/AIDS, previous history of deep vein thrombosis or pulmonary embolism, and nephritic syndrome (https://my.clevelandclinic.org/health/diseases/16788). Factors associated with hypercoagulable do react, for instance, usual coagulation is instigated by the release of tissue factor due to flawed tissues. Tissue factor hence binds to circulating factor VIIa and the incarnation stimulate factor X to factor Xa and factor IX to factor IXa and this ends up activating prothrombin which leads to thrombin.
To find what is wrong with the patient several laboratory tests needs to be done in order to diagnose the cause of the patient’s right calf swelling. Several blood tests should be carried out to measure the levels and activity of the natural anticoagulants in the patient’s blood. Several tests are encouraged to confirm the results because sometimes false positive results occur. For instance, pregnancy and contraceptive pills often cause false results of a low level of protein S. The foremost consequence of anticoagulant therapy is extreme bleeding (Haemorrhage). Haemorrhage occurs due to the use of anticoagulant medicines which decreases formation of blood clots (https://www.nhs.uk/conditions/anticoagulants/side-effects/). Excessive bleeding occurs in various methods such as vomiting blood, prolonged and frequent nose bleeding or bleeding of gums.
Lipe, B. & Ornestein, D. (2011). Deficiencies of Natural Anticoagulants, Protein C, Protein S, and Antithrombin
Orrange, S. (2019). These 7 Medications can Cause Puffy Legs and Ankles. https://www.goodrx.com/blog/these-7-medications-can-cause-puffy-legs-and-ankles/