Sample Paper on Comparative Effective Research in the American health care system

Comparative Effective Research

The critical role comparative effective research in the American health care system is an implementation whose success cannot be under-estimated due to its fundamental opportunities with regard to decision making among the policy makers and every individual involved in the health care set-up. The study that adopted the comparative effective research was the Clinical Antipsychotic Trials of Intervention Effectiveness

The introduction of the antipsychotic medication in 1954 was coupled with a major side effect including tardive dyskinesia regarded as the first generation drug. The Food Drug Administration (FDA) approved the second generation of antipsychotic medication, clozapine which had lesser side effects in 1990 (Olsen, Grossmann, McGinnis, & Institute of Medicine, 2011). The disparity involving the initial and subsequent cohort prescription was afterwards regarded to as a typical antipsychotic. The fallout of two major researches were convened on the phenomenon of atypical antipsychotics in 2003. On comparison, they were found to be equally efficient and posed the same risks in terms time of symptoms while the quality was similar. It was however evident that the second generation medication had a slight superiority.

Schizophrenia treatment has not been effective due to the uncertainties concerning the handling of psychotic symptoms, the severe side effects and the high cost of medication. These issues derive the need for second-generation antipsychotic assessment. The interpretation and implementation of the results had a number of difficulties in making prediction due to beliefs about the lack of strength and efficiency of the second generation medication. Changing the belief was not easy since the society’s belief were not easily persuaded by the research findings by the industry. It s however notable that analysts of the two second study did not concentrate on its shortcomings such as the failure to address the side effects did not have a role in carrying out prescriptions.


Olsen, L. A., Grossmann, C., McGinnis, J. M. & Institute of Medicine (U.S.). (2011). learning what works: Infrastructure required for comparative effectiveness research: workshop summary. Washington, D.C: National Academies Press.